5Z1C

The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4

Summary for 5Z1C

• Entry DOI: 10.2210/pdb5z1c/pdb
• Descriptor: Urokinase-type plasminogen activator, 1-(4-iodophenyl)methanamine (3 entities in total)
• Functional Keywords: halogen bonding, serine protease, upa, p1 group, protease inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 27819.47

Authors

Jiang, L.G.,Zhang, X.,Luo, Z.P.,Huang, M.D. (deposition date: 2017-12-25, release date: 2018-12-26, Last modification date: 2023-11-22)

• Primary citation: Jiang, L.G.,Zhang, X.,Zhou, Y.,Chen, Y.Y.,Luo, Z.P.,Li, J.Y.,Yuan, C.,Huang, M.D.; Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases; Rsc Adv, 49:28189-28197, 2018; DOI: 10.1039/c8ra03145b

Experimental method

X-RAY DIFFRACTION (1.45 Å)