5YUP

Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5

Summary for 5YUP

• Entry DOI: 10.2210/pdb5yup/pdb
• Descriptor: the heavy chain of the Fab fragment of FVIIa antibody mAb4F5, the light chain of the Fab fragment of FVIIa antibody mAb4F5 (3 entities in total)
• Functional Keywords: fviia, antibodies, fab4f5, inhibition, coagulation, structural protein, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47423.72

Authors

Jiang, L.G.,Persson, E.,Huang, M.D. (deposition date: 2017-11-22, release date: 2019-06-19, Last modification date: 2024-10-23)

Primary citation

Jiang, L.G.,Xie, X.,Li, J.,Persson, E.,Huang, M.D.
Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism.
Res Pract Thromb Haemost, 3:412-419, 2019

PubMed Abstract: Blood coagulation factor VIIa (FVIIa) plays its critical physiological role in the initiation of hemostasis. Even so, recombinant FVIIa is successfully used as a bypassing agent for factor VIII or IX in the treatment of bleeds in patients with severe hemophilia with inhibitors. To investigate the utility of more potent FVIIa variants with enhanced intrinsic activity, molecules such as V21D/E154V/M156Q-FVIIa (FVIIa) were designed.

PubMed: 31294329
DOI: 10.1002/rth2.12211

Experimental method

X-RAY DIFFRACTION (1.81 Å)