5ZC5
uPA-NU-09F
Summary for 5ZC5
Entry DOI | 10.2210/pdb5zc5/pdb |
Descriptor | Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide (3 entities in total) |
Functional Keywords | upa, inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 28853.81 |
Authors | Jiang, L.G.,Buckley, B.J.,Huang, M.D.,Kelso, M.J.,Ranson, M. (deposition date: 2018-02-15, release date: 2018-12-19, Last modification date: 2023-11-22) |
Primary citation | Buckley, B.J.,Aboelela, A.,Minaei, E.,Jiang, L.X.,Xu, Z.,Ali, U.,Fildes, K.,Cheung, C.Y.,Cook, S.M.,Johnson, D.C.,Bachovchin, D.A.,Cook, G.M.,Apte, M.,Huang, M.,Ranson, M.,Kelso, M.J. 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J. Med. Chem., 61:8299-8320, 2018 Cited by PubMed: 30130401DOI: 10.1021/acs.jmedchem.8b00838 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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