Author results

3P57
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CRYSTAL STRUCTURE OF THE P300 TAZ2 DOMAIN BOUND TO MEF2 ON DNA
Descriptor:Myocyte-specific enhancer factor 2A, DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), ...
Authors:He, J., Ye, J., Riquelme, C., Liu, J.O.
Deposit date:2010-10-08
Release date:2011-08-10
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1921 Å)
Cite:Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
4BH6
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INSIGHTS INTO DEGRON RECOGNITION BY APC COACTIVATORS FROM THE STRUCTURE OF AN ACM1-CDH1 COMPLEX
Descriptor:APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1
Authors:He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D.
Deposit date:2013-03-29
Release date:2013-06-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex.
Mol.Cell, 50, 2013
3RCP
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CRYSTAL STRUCTURE OF THE FAPP1 PLECKSTRIN HOMOLOGY DOMAIN
Descriptor:Pleckstrin homology domain-containing family A member 3, GLYCEROL
Authors:Roy, S., He, J., Kutateladze, T.G.
Deposit date:2011-03-31
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain.
J.Biol.Chem., 286, 2011
4ADY
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CRYSTAL STRUCTURE OF 26S PROTEASOME SUBUNIT RPN2
Descriptor:26S PROTEASOME REGULATORY SUBUNIT RPN2
Authors:Kulkarni, K., He, J., Da Fonseca, P.C.A., Krutauz, D., Glickman, M.H., Barford, D., Morris, E.P.
Deposit date:2012-01-04
Release date:2012-03-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
5ZGD
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HNRNPA1 REVERSIBLE AMYLOID CORE GFGGNDNFG (RESIDUES 209-217) DETERMINED BY X-RAY
Descriptor:GLY-PHE-GLY-GLY-ASN-ASP-ASN-PHE-GLY
Authors:Gui, X., Xie, M., Zhao, M., Luo, F., He, J., Li, D., Liu, C.
Deposit date:2018-03-08
Release date:2019-04-03
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
5ZGL
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HNRNP A1 SEGMENT GGGYGGS (RESIDUES 234-240)
Descriptor:7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1
Authors:Xie, M., Luo, F., Gui, X., Zhao, M., He, J., Li, D., Liu, C.
Deposit date:2018-03-09
Release date:2019-04-03
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
3TI3
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI4
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI5
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI6
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH OSELTAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI8
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIA
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIB
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIC
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
4H32
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THE CRYSTAL STRUCTURE OF THE HEMAGGLUTININ H17 DERIVED THE BAT INFLUENZA A VIRUS
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE
Authors:Sun, X., Shi, Y., Lu, X., He, J., Gao, F., Yan, J., Qi, J., Gao, G.F.
Deposit date:2012-09-13
Release date:2013-07-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism.
Cell Rep, 3, 2013
4L8Z
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH RL1
Descriptor:Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
Authors:Li, J., Ren, J., Yang, M., Xiong, B., He, J.
Deposit date:2013-06-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
4L90
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH RL3
Descriptor:Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](4-methylpiperazin-1-yl)methanone
Authors:Li, J., Ren, J., Yang, M., Xiong, B., He, J.
Deposit date:2013-06-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structure of Human Hsp90 with RL3
to be published
4L91
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH X29
Descriptor:Heat shock protein HSP 90-alpha, 4-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-chlorobenzene-1,3-diol
Authors:Li, J., Ren, J., Yang, M., Xiong, B., He, J.
Deposit date:2013-06-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
4L93
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S36
Descriptor:Heat shock protein HSP 90-alpha, 3,4-dihydroisoquinolin-2(1H)-yl[2,4-dihydroxy-5-(propan-2-yl)phenyl]methanone
Authors:Li, J., Ren, J., Yang, M., Xiong, B., He, J.
Deposit date:2013-06-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:Crystal structure of Human Hsp90 with S36
To be Published
4L94
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CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S46
Descriptor:Heat shock protein HSP 90-alpha, (4-hydroxyphenyl)(4-methylpiperazin-1-yl)methanone
Authors:Li, J., Ren, J., Yang, M., Xiong, B., He, J.
Deposit date:2013-06-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
Bioorg.Med.Chem.Lett., 24, 2014
4LWE
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ2
Descriptor:Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide
Authors:Li, J., Shi, F., Xiong, B., He, J.
Deposit date:2013-07-27
Release date:2014-07-30
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWF
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ3
Descriptor:Heat shock protein HSP 90-alpha, 4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol
Authors:Li, J., Shi, F., Xiong, B., He, J.
Deposit date:2013-07-27
Release date:2014-07-30
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWG
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ4
Descriptor:Heat shock protein HSP 90-alpha, 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Authors:Li, J., Shi, F., Xiong, B., He, J.
Deposit date:2013-07-27
Release date:2014-07-30
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWH
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ5
Descriptor:Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazol-5-yl}cyclopropanecarboxamide
Authors:Li, J., Shi, F., Xiong, B., He, J.
Deposit date:2013-07-27
Release date:2014-07-30
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014
4LWI
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ6
Descriptor:Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide
Authors:Li, J., Shi, F., Xiong, B., He, J.
Deposit date:2013-07-27
Release date:2014-07-30
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87, 2014