Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA

Summary for 3P57

DescriptorMyocyte-specific enhancer factor 2A, DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), ... (6 entities in total)
Functional Keywordsprotein-dna complex, transcription factor, transcriptional activation, p300, zinc finger, transferase-transcription activator-dna complex, transferase/transcription activator/dna
Biological sourceHomo sapiens (human)
Total number of polymer chains13
Total molecular weight104442.81
He, J.,Ye, J.,Riquelme, C.,Liu, J.O. (deposition date: 2010-10-08, release date: 2011-08-10, Last modification date: 2019-07-17)
Primary citation
He, J.,Ye, J.,Cai, Y.,Riquelme, C.,Liu, J.O.,Liu, X.,Han, A.,Chen, L.
Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39:4464-4474, 2011
PubMed: 21278418 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkr030
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.265130 4.3% 9.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-18