3P57

Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046983	molecular_function	protein dimerization activity
B	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046983	molecular_function	protein dimerization activity
C	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046983	molecular_function	protein dimerization activity
I	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
I	0003677	molecular_function	DNA binding
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046983	molecular_function	protein dimerization activity
J	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
J	0003677	molecular_function	DNA binding
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046983	molecular_function	protein dimerization activity
P	0004402	molecular_function	histone acetyltransferase activity
P	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 120

Chain	Residue
P	HIS22
P	CYS26
P	CYS31
P	CYS36

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 121

Chain	Residue
P	HIS45
P	CYS49
P	CYS57
P	CYS60

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN P 122

Chain	Residue
P	CYS74
P	CYS79
P	VAL81
P	CYS84
P	HIS70

---

Functional Information from PROSITE/UniProt

site_id	PS00350
Number of Residues	55
Details	MADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnssnkLfqY

Chain	Residue	Details
A	ARG3-TYR57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	324
Details	Domain: {"description":"MADS-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00251","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	DNA binding: {"description":"Mef2-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---