6CFH
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6CB9
| Segment AALQSS from the low complexity domain of TDP-43, residues 328-333 | Descriptor: | AALQSS | Authors: | Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-02-02 | Release date: | 2018-04-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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6CEW
| Segment AMMAAA from the low complexity domain of TDP-43, residues 321-326 | Descriptor: | AMMAAA | Authors: | Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-02-12 | Release date: | 2018-04-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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6CF4
| Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low complexity domain of TDP-43, residues 312-317 | Descriptor: | NFGTFS | Authors: | Guenther, E.L, Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-02-13 | Release date: | 2018-05-23 | Last modified: | 2021-06-30 | Method: | ELECTRON CRYSTALLOGRAPHY (0.75 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5W50
| Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-06-13 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat. Struct. Mol. Biol., 25, 2018
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5W52
| MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-06-13 | Release date: | 2018-02-21 | Last modified: | 2024-04-03 | Method: | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | Cite: | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat. Struct. Mol. Biol., 25, 2018
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5WIA
| Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43, residues 370-375 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-18 | Release date: | 2018-04-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.002 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WKD
| Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-07-25 | Release date: | 2018-04-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WHN
| Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43, residues 312-317 | Descriptor: | Segment of TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-17 | Release date: | 2018-04-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5W7V
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5WHP
| Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317 | Descriptor: | Segment of TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-17 | Release date: | 2018-05-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WIQ
| Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-19 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WKB
| MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-07-24 | Release date: | 2018-05-23 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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4RIK
| Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77 | Descriptor: | Alpha-synuclein | Authors: | Guenther, E.L, Sawaya, M.R, Ivanova, M, Eisenberg, D.S. | Deposit date: | 2014-10-06 | Release date: | 2015-08-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.854 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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4RIL
| Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2014-10-06 | Release date: | 2015-08-26 | Last modified: | 2023-09-20 | Method: | ELECTRON CRYSTALLOGRAPHY (1.43 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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4ZNN
| MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2015-05-05 | Release date: | 2015-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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5DLI
| Corkscrew assembly of SOD1 residues 28-38 | Descriptor: | GLYCEROL, IODIDE ION, Superoxide dismutase [Cu-Zn] | Authors: | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2015-09-05 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5IIW
| Corkscrew assembly of SOD1 residues 28-38 without potassium iodide | Descriptor: | Superoxide dismutase [Cu-Zn] | Authors: | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2016-03-01 | Release date: | 2017-06-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4NIP
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4NIN
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4NIO
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3I58
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3I53
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3I64
| Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH) and 1,4-dihydroxy-2-naphthoic acid (DHN) | Descriptor: | 1,4-dihydroxy-2-naphthoic acid, GLYCEROL, O-methyltransferase, ... | Authors: | Cooke, H.A, Bruner, S.D. | Deposit date: | 2009-07-06 | Release date: | 2009-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry, 48, 2009
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3I5U
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