4NIO

GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis

Summary for 4NIO

Entry DOI	10.2210/pdb4nio/pdb
Related	4NIN 4NIP
Descriptor	GVTGIAQ segment from Superoxide dismutase [Cu-Zn] (2 entities in total)
Functional Keywords	steric zipper, cross-beta spine, amyloid fiber, protein fibril
Biological source	Homo Sapiens (human)
Cellular location	Cytoplasm : P00441
Total number of polymer chains	1
Total formula weight	644.72
Authors	Sievers, S.A.,Sawaya, M.R.,Eisenberg, D.,Ivanova, M.I. (deposition date: 2013-11-06, release date: 2013-12-04, Last modification date: 2024-02-28)
Primary citation	Ivanova, M.I.,Sievers, S.A.,Guenther, E.L.,Johnson, L.M.,Winkler, D.D.,Galaleldeen, A.,Sawaya, M.R.,Hart, P.J.,Eisenberg, D.S. Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc.Natl.Acad.Sci.USA, 111:197-201, 2014 Cited by PubMed: 24344300 DOI: 10.1073/pnas.1320786110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation