4RIL
Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction
Summary for 4RIL
Entry DOI | 10.2210/pdb4ril/pdb |
EMDB information | 3028 |
Descriptor | Alpha-synuclein (2 entities in total) |
Functional Keywords | amyloid, alpha-synuclein, parkinson's disease, toxic core, nacore, lipid binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol : P37840 |
Total number of polymer chains | 1 |
Total formula weight | 944.08 |
Authors | Rodriguez, J.A.,Ivanova, M.,Sawaya, M.R.,Cascio, D.,Reyes, F.,Shi, D.,Johnson, L.,Guenther, E.,Sangwan, S.,Hattne, J.,Nannenga, B.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S. (deposition date: 2014-10-06, release date: 2015-08-26, Last modification date: 2023-09-20) |
Primary citation | Rodriguez, J.A.,Ivanova, M.I.,Sawaya, M.R.,Cascio, D.,Reyes, F.E.,Shi, D.,Sangwan, S.,Guenther, E.L.,Johnson, L.M.,Zhang, M.,Jiang, L.,Arbing, M.A.,Nannenga, B.L.,Hattne, J.,Whitelegge, J.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S. Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525:486-490, 2015 Cited by PubMed: 26352473DOI: 10.1038/nature15368 PDB entries with the same primary citation |
Experimental method | ELECTRON CRYSTALLOGRAPHY (1.43 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)