6CF4

Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low complexity domain of TDP-43, residues 312-317

Summary for 6CF4

Entry DOI	10.2210/pdb6cf4/pdb
Related	5WHN 5WHP 5WKB
EMDB information	7466
Descriptor	NFGTFS (2 entities in total)
Functional Keywords	amyloid, larks, reversible aggregation, protein fibril
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	751.68
Authors	Guenther, E.L.,Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2018-02-13, release date: 2018-05-23, Last modification date: 2021-06-30)
Primary citation	Guenther, E.L.,Cao, Q.,Trinh, H.,Lu, J.,Sawaya, M.R.,Cascio, D.,Boyer, D.R.,Rodriguez, J.A.,Hughes, M.P.,Eisenberg, D.S. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25:463-471, 2018 Cited by PubMed: 29786080 DOI: 10.1038/s41594-018-0064-2 PDB entries with the same primary citation
Experimental method	ELECTRON CRYSTALLOGRAPHY (0.75 Å)

Structure validation