5WHP

Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317

Summary for 5WHP

Entry DOI	10.2210/pdb5whp/pdb
Descriptor	Segment of TAR DNA-binding protein 43 (2 entities in total)
Functional Keywords	amyloid, larks, tdp-43, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	671.70
Authors	Guenther, E.L.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2017-07-17, release date: 2018-05-23, Last modification date: 2024-03-13)
Primary citation	Guenther, E.L.,Cao, Q.,Trinh, H.,Lu, J.,Sawaya, M.R.,Cascio, D.,Boyer, D.R.,Rodriguez, J.A.,Hughes, M.P.,Eisenberg, D.S. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25:463-471, 2018 Cited by PubMed: 29786080 DOI: 10.1038/s41594-018-0064-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation