3I5U
Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosylmethionine (SAM) and 2-hydroxy-5-methyl naphthoic acid (MNA)
Summary for 3I5U
Entry DOI | 10.2210/pdb3i5u/pdb |
Related | 3I53 3I58 3I64 |
Descriptor | O-methyltransferase, S-ADENOSYLMETHIONINE, 2-hydroxy-5-methyl naphthoic acid, ... (5 entities in total) |
Functional Keywords | co-complex, rossmann-like fold, methyltransferase, transferase |
Biological source | Streptomyces carzinostaticus subsp. neocarzinostaticus |
Total number of polymer chains | 2 |
Total formula weight | 70651.68 |
Authors | Cooke, H.A.,Bruner, S.D. (deposition date: 2009-07-06, release date: 2009-09-01, Last modification date: 2023-09-06) |
Primary citation | Cooke, H.A.,Guenther, E.L.,Luo, Y.,Shen, B.,Bruner, S.D. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry, 48:9590-9598, 2009 Cited by PubMed: 19702337DOI: 10.1021/bi901257q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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