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5AFW
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BU of 5afw by Molmil
Assembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, ...
Authors:Metzger, E, Willmann, D, McMillan, J, Petroll, K, Metzger, P, Gerhardt, S, vonMaessenhausen, A, Schott, A.K, Espejo, A, Eberlin, A, Wohlwend, D, Schuele, K.M, Schleicher, M, Perner, S, Bedford, M.T, Dengjel, J, Flaig, R, Einsle, O, Schuele, R.
Deposit date:2015-01-26
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation.
Nat.Struct.Mol.Biol., 23, 2016
3HFH
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BU of 3hfh by Molmil
Crystal structure of tandem FF domains
Descriptor: Transcription elongation regulator 1
Authors:Lu, M, Yang, J, Ren, Z, Subir, S, Bedford, M.T, Jacobson, R.H, McMurray, J.S, Chen, X.
Deposit date:2009-05-11
Release date:2009-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150.
J.Mol.Biol., 393, 2009
2GF7
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BU of 2gf7 by Molmil
Double tudor domain structure
Descriptor: Jumonji domain-containing protein 2A, SULFATE ION
Authors:Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M.
Deposit date:2006-03-21
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Science, 312, 2006
2JTF
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BU of 2jtf by Molmil
Solution Structure of the PHF20L1 MBT domain
Descriptor: PHD finger protein 20-like 1
Authors:Brockmann, C, Iberg, A.N, Rehbein, K, Diehl, A, Bedford, M.T, Oschkinat, H.
Deposit date:2007-07-30
Release date:2008-08-19
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural Analysis of Histone H4K20 Methyllysine Recognition by the MBT Domain of PHF20L1
To be Published
2GFA
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BU of 2gfa by Molmil
double tudor domain complex structure
Descriptor: Jumonji domain-containing protein 2A, peptide
Authors:Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M.
Deposit date:2006-03-21
Release date:2006-05-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Science, 312, 2006
3QO2
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BU of 3qo2 by Molmil
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9
Descriptor: 1,2-ETHANEDIOL, Histone H3 peptide, M-phase phosphoprotein 8
Authors:Chang, Y, Horton, J.R, Bedford, M.T, Zhang, X, Cheng, X.
Deposit date:2011-02-09
Release date:2011-04-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.
J.Mol.Biol., 408, 2011
4QQ6
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BU of 4qq6 by Molmil
Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule
Descriptor: 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, Survival motor neuron protein, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Iqbal, A, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2014-06-26
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13, 2022
4QQD
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BU of 4qqd by Molmil
Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule
Descriptor: 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, E3 ubiquitin-protein ligase UHRF1, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Iqbal, A, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-08-06
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13, 2022
2LDM
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BU of 2ldm by Molmil
Solution structure of human PHF20 Tudor2 domain bound to a p53 segment containing a dimethyllysine analog p53K370me2
Descriptor: Uncharacterized protein
Authors:Cui, G, Botuyan, M, Mer, G.
Deposit date:2011-05-30
Release date:2012-05-30
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
4CRI
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BU of 4cri by Molmil
Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide
Descriptor: RB1 PROTEIN, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1
Authors:Krojer, T, Johansson, C, Gileadi, C, Fedorov, O, Carr, S, La Thangue, N.B, Vollmar, M, Crawley, L, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U.
Deposit date:2014-02-26
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Lysine Methylation-Dependent Binding of 53BP1 to the Prb Tumor Suppressor.
Proc.Natl.Acad.Sci.USA, 111, 2014
8F8Y
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BU of 8f8y by Molmil
PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide
Descriptor: 1,2-ETHANEDIOL, Lysine-specific demethylase PHF2, SULFATE ION, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2022-11-22
Release date:2023-01-18
Last modified:2023-02-08
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
J.Biol.Chem., 299, 2022
8F8Z
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BU of 8f8z by Molmil
PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide
Descriptor: 1,2-ETHANEDIOL, H3 N-Terminal Peptide, Lysine-specific demethylase PHF2, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2022-11-22
Release date:2023-01-18
Last modified:2023-02-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
J.Biol.Chem., 299, 2022
3MO0
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BU of 3mo0 by Molmil
Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11
Descriptor: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ...
Authors:Chang, Y, Horton, J.R, Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3MO5
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BU of 3mo5 by Molmil
Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72
Descriptor: 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ...
Authors:Chang, Y, Horton, J.R, Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3MO2
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BU of 3mo2 by Molmil
human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67
Descriptor: 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ...
Authors:Chang, Y, Horton, J.R, Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3FPD
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BU of 3fpd by Molmil
G9a-like protein lysine methyltransferase inhibition by BIX-01294
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine, ...
Authors:Chang, Y, Zhang, X, Horton, J.R, Cheng, X.
Deposit date:2009-01-05
Release date:2009-02-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Nat.Struct.Mol.Biol., 16, 2009
7NUE
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BU of 7nue by Molmil
Crystal structure of mouse PRMT6 in complex with inhibitor EML736
Descriptor: Protein arginine N-methyltransferase 6, methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
Authors:Bonnefond, L, Cavarelli, J.
Deposit date:2021-03-11
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7NUD
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BU of 7nud by Molmil
Crystal structure of mouse PRMT6 in complex with inhibitor EML734
Descriptor: Protein arginine N-methyltransferase 6, methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
Authors:Bonnefond, L, Cavarelli, J.
Deposit date:2021-03-11
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7P2R
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BU of 7p2r by Molmil
Crystal structure of mouse PRMT6 in complex with inhibitor EML980
Descriptor: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
Authors:Bonnefond, L, Cavarelli, J.
Deposit date:2021-07-06
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
6WE9
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BU of 6we9 by Molmil
YTH domain of human YTHDC1 with 11mer ssDNA Containing N6mA
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*CP*TP*G)-3'), GLYCEROL, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2020-04-01
Release date:2020-07-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.
Nucleic Acids Res., 48, 2020
6WEA
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BU of 6wea by Molmil
YTH domain of human YTHDC1 with a 10mer Oligo Containing N6mA
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*TP*C)-3'), SODIUM ION, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2020-04-01
Release date:2020-07-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.
Nucleic Acids Res., 48, 2020
6WE8
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BU of 6we8 by Molmil
YTH domain of human YTHDC1
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2020-04-01
Release date:2020-07-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.
Nucleic Acids Res., 48, 2020
7W2P
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BU of 7w2p by Molmil
Tudor domain of SMN in complex with a small molecule
Descriptor: 2-[(4-fluorophenyl)methyl]-2-azatricyclo[7.3.0.0^{3,7}]dodeca-1(9),3(7)-dien-8-imine, MAGNESIUM ION, Survival motor neuron protein, ...
Authors:Li, W, Arrowsmith, C.H, Edwards, A.M, Liu, Y, Min, J.
Deposit date:2021-11-24
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13, 2022
7W30
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BU of 7w30 by Molmil
Tudor domain of SMN in complex with a small molecule
Descriptor: 1,2-dimethylquinolin-4-imine, Survival motor neuron protein, UNKNOWN ATOM OR ION
Authors:Li, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Liu, Y, Min, J.
Deposit date:2021-11-24
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13, 2022
3P8D
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BU of 3p8d by Molmil
Crystal structure of the second Tudor domain of human PHF20 (homodimer form)
Descriptor: Medulloblastoma antigen MU-MB-50.72
Authors:Cui, G, Lee, J, Thompson, J.R, Botuyan, M.V, Mer, G.
Deposit date:2010-10-13
Release date:2011-06-22
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012

 

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