3MO0
Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11
Summary for 3MO0
Entry DOI | 10.2210/pdb3mo0/pdb |
Related | 3FPD 3MO2 3MO5 |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine, ... (6 entities in total) |
Functional Keywords | epigenetics, histone lysine methylation, enzymatic inhibition, lysine mimics, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9H9B1 |
Total number of polymer chains | 2 |
Total formula weight | 68643.38 |
Authors | Chang, Y.,Horton, J.R.,Cheng, X. (deposition date: 2010-04-22, release date: 2010-06-30, Last modification date: 2023-09-06) |
Primary citation | Chang, Y.,Ganesh, T.,Horton, J.R.,Spannhoff, A.,Liu, J.,Sun, A.,Zhang, X.,Bedford, M.T.,Shinkai, Y.,Snyder, J.P.,Cheng, X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400:1-7, 2010 Cited by PubMed: 20434463DOI: 10.1016/j.jmb.2010.04.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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