3MO0

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5	polymer	285	32830.2	2	UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856)	Homo sapiens (human)	Histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, G9a-like protein 1, GLP1, Lysine N-methyltransferase 1D
2	C, M (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
3	D, J, N (A, B)	N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine	non-polymer		478.6	3	Chemie (E11)
4	E, F, G, H, I... (A, B)	ZINC ION	non-polymer		65.4	10	Chemie (ZN)
5	K, L (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	T, U (A, B)	water	water		18.0	44	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65660.4
Non-Polymers*	Number of molecules	17
	Total formula weight	2982.9
All*	Total formula weight	68643.4

*Water molecules are not included.