3MO5
Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72
Summary for 3MO5
Entry DOI | 10.2210/pdb3mo5/pdb |
Related | 3FPD 3MO0 3MO2 |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, ... (5 entities in total) |
Functional Keywords | epigenetics, histone lysine methylation, enzymatic inhibition, lysine mimics, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9H9B1 |
Total number of polymer chains | 4 |
Total formula weight | 135315.35 |
Authors | Chang, Y.,Horton, J.R.,Cheng, X. (deposition date: 2010-04-22, release date: 2010-06-30, Last modification date: 2023-09-06) |
Primary citation | Chang, Y.,Ganesh, T.,Horton, J.R.,Spannhoff, A.,Liu, J.,Sun, A.,Zhang, X.,Bedford, M.T.,Shinkai, Y.,Snyder, J.P.,Cheng, X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400:1-7, 2010 Cited by PubMed: 20434463DOI: 10.1016/j.jmb.2010.04.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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