3MO5
Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 | polymer | 285 | 32830.2 | 4 | UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (human) | Histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, G9a-like protein 1, GLP1, Lysine N-methyltransferase 1D |
| 2 | E, F, G, H, J... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 3 | I, N, T, Z (A, B, C, D) | 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine | non-polymer | 544.8 | 4 | Chemie (E72) | |||
| 4 | S, Y (C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 5 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 699 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 131320.9 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3994.5 | |
| All* | Total formula weight | 135315.3 |
