3MO5

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0046974	molecular_function	histone H3K9 methyltransferase activity
B	0002039	molecular_function	p53 binding
B	0005634	cellular_component	nucleus
B	0008270	molecular_function	zinc ion binding
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0042054	molecular_function	histone methyltransferase activity
B	0046974	molecular_function	histone H3K9 methyltransferase activity
C	0002039	molecular_function	p53 binding
C	0005634	cellular_component	nucleus
C	0008270	molecular_function	zinc ion binding
C	0016279	molecular_function	protein-lysine N-methyltransferase activity
C	0042054	molecular_function	histone methyltransferase activity
C	0046974	molecular_function	histone H3K9 methyltransferase activity
D	0002039	molecular_function	p53 binding
D	0005634	cellular_component	nucleus
D	0008270	molecular_function	zinc ion binding
D	0016279	molecular_function	protein-lysine N-methyltransferase activity
D	0042054	molecular_function	histone methyltransferase activity
D	0046974	molecular_function	histone H3K9 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS1031
A	CYS1044
A	CYS1074
A	CYS1078

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	ZN3
A	CYS1037
A	CYS1074
A	CYS1080
A	CYS1084

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	ZN2
A	CYS1031
A	CYS1033
A	CYS1037
A	CYS1042

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4

Chain	Residue
A	CYS1172
A	CYS1225
A	CYS1227
A	CYS1232

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE E72 A 1236

Chain	Residue
A	HOH245
A	HOH672
A	HOH674
A	TYR1124
A	ASP1131
A	ALA1134
A	ASP1135
A	ARG1137
A	ASP1140
A	SER1141
A	LEU1143
A	ASP1145
A	TYR1211
A	ARG1214
A	PHE1215
A	LYS1219

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 5

Chain	Residue
B	ZN7
B	CYS1031
B	CYS1044
B	CYS1074
B	CYS1078

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 6

Chain	Residue
B	CYS1037
B	CYS1074
B	CYS1080
B	CYS1084

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 7

Chain	Residue
B	ZN5
B	CYS1031
B	CYS1033
B	CYS1037
B	CYS1042

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 8

Chain	Residue
B	CYS1172
B	CYS1225
B	CYS1227
B	CYS1232

---

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE E72 B 2

Chain	Residue
B	HOH86
B	HOH197
B	ASP1131
B	ALA1134
B	ASP1135
B	VAL1136
B	ARG1137
B	ASP1140
B	SER1141
B	LEU1143
B	ASP1145
B	TYR1211
B	ARG1214
B	PHE1215
B	ILE1218
B	LYS1219
D	HOH153
D	ASP1022
D	ARG1189

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	ZN2
C	CYS1031
C	CYS1044
C	CYS1074
C	CYS1078

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 2

Chain	Residue
C	ZN1
C	CYS1037
C	CYS1074
C	CYS1080
C	CYS1084

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 3

Chain	Residue
C	CYS1031
C	CYS1033
C	CYS1037
C	CYS1042

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 4

Chain	Residue
C	CYS1172
C	CYS1225
C	CYS1227
C	CYS1232

---

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH C 103

Chain	Residue
C	ARG1226
C	CYS1227
C	HOH362
C	MET1105
C	GLY1106
C	TRP1107
C	TYR1142
C	ARG1166
C	ASN1169
C	HIS1170
C	TYR1211
C	CYS1225

---

site_id	BC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE E72 C 1236

Chain	Residue
A	HOH132
A	HOH244
A	ASP1022
A	GLU1152
A	ASP1187
A	ARG1189
C	HOH172
C	HOH398
C	ASP1131
C	ALA1134
C	ASP1135
C	ASP1140
C	SER1141
C	LEU1143
C	ASP1145
C	TYR1211
C	ARG1214
C	PHE1215
C	LYS1219

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 5

Chain	Residue
D	HOH548
D	CYS1031
D	CYS1044
D	CYS1074
D	CYS1078

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 6

Chain	Residue
D	HOH548
D	CYS1037
D	CYS1074
D	CYS1080
D	CYS1084

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 7

Chain	Residue
D	CYS1031
D	CYS1033
D	CYS1037
D	CYS1042

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 8

Chain	Residue
D	CYS1172
D	CYS1225
D	CYS1227
D	CYS1232

---

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH D 104

Chain	Residue
D	MET1105
D	GLY1106
D	TRP1107
D	TYR1142
D	ARG1166
D	ASN1169
D	HIS1170
D	TYR1211
D	PHE1215
D	PHE1223
D	CYS1225
D	ARG1226

---

site_id	CC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE E72 D 4

Chain	Residue
D	HOH453
D	ASP1131
D	ALA1134
D	ASP1135
D	VAL1136
D	ARG1137
D	ASP1140
D	SER1141
D	LEU1143
D	ASP1145
D	TYR1211
D	ARG1214
D	PHE1215
D	ILE1218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Interaction with histone H3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Histone H3K9me binding","evidences":[{"source":"PubMed","id":"18264113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---