3MO5

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72

Summary for 3MO5

• Entry DOI: 10.2210/pdb3mo5/pdb
• Related: 3FPD 3MO0 3MO2
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, ... (5 entities in total)
• Functional Keywords: epigenetics, histone lysine methylation, enzymatic inhibition, lysine mimics, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9H9B1
• Total number of polymer chains: 4
• Total formula weight: 135315.35

Authors

Chang, Y.,Horton, J.R.,Cheng, X. (deposition date: 2010-04-22, release date: 2010-06-30, Last modification date: 2023-09-06)

• Primary citation: Chang, Y.,Ganesh, T.,Horton, J.R.,Spannhoff, A.,Liu, J.,Sun, A.,Zhang, X.,Bedford, M.T.,Shinkai, Y.,Snyder, J.P.,Cheng, X.; Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.; J.Mol.Biol., 400:1-7, 2010; PubMed: 20434463; DOI: 10.1016/j.jmb.2010.04.048

Experimental method

X-RAY DIFFRACTION (2.14 Å)