5AFW
Assembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation
Summary for 5AFW
Entry DOI | 10.2210/pdb5afw/pdb |
Descriptor | CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | hydrolase, lsd1k114me2, androgen receptor, chd1, g9a, prostate cancer, tmprrs2-erg |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus : O14646 O60341 |
Total number of polymer chains | 2 |
Total formula weight | 22725.66 |
Authors | Metzger, E.,Willmann, D.,McMillan, J.,Petroll, K.,Metzger, P.,Gerhardt, S.,vonMaessenhausen, A.,Schott, A.K.,Espejo, A.,Eberlin, A.,Wohlwend, D.,Schuele, K.M.,Schleicher, M.,Perner, S.,Bedford, M.T.,Dengjel, J.,Flaig, R.,Einsle, O.,Schuele, R. (deposition date: 2015-01-26, release date: 2016-01-13, Last modification date: 2024-01-10) |
Primary citation | Metzger, E.,Willmann, D.,Mcmillan, J.,Forne, I.,Metzger, P.,Gerhardt, S.,Petroll, K.,Von Maessenhausen, A.,Urban, S.,Schott, A.,Espejo, A.,Eberlin, A.,Wohlwend, D.,Schule, K.M.,Schleicher, M.,Perner, S.,Bedford, M.T.,Jung, M.,Dengjel, J.,Flaig, R.,Imhof, A.,Einsle, O.,Schule, R. Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation. Nat.Struct.Mol.Biol., 23:132-, 2016 Cited by PubMed: 26751641DOI: 10.1038/NSMB.3153 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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