6WE9

YTH domain of human YTHDC1 with 11mer ssDNA Containing N6mA

Summary for 6WE9

• Entry DOI: 10.2210/pdb6we9/pdb
• Descriptor: YTH domain-containing protein 1, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*CP*TP*G)-3'), 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: n6-methyladenine binding protein domain, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 45090.80

Authors

Horton, J.R.,Cheng, X. (deposition date: 2020-04-01, release date: 2020-07-15, Last modification date: 2023-10-18)

• Primary citation: Woodcock, C.B.,Horton, J.R.,Zhou, J.,Bedford, M.T.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.; Nucleic Acids Res., 48:10329-10341, 2020; PubMed: 32663306; DOI: 10.1093/nar/gkaa604

Experimental method

X-RAY DIFFRACTION (1.59 Å)