6WE9
YTH domain of human YTHDC1 with 11mer ssDNA Containing N6mA
Summary for 6WE9
Entry DOI | 10.2210/pdb6we9/pdb |
Descriptor | YTH domain-containing protein 1, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*CP*TP*G)-3'), 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | n6-methyladenine binding protein domain, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 45090.80 |
Authors | Horton, J.R.,Cheng, X. (deposition date: 2020-04-01, release date: 2020-07-15, Last modification date: 2023-10-18) |
Primary citation | Woodcock, C.B.,Horton, J.R.,Zhou, J.,Bedford, M.T.,Blumenthal, R.M.,Zhang, X.,Cheng, X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res., 48:10329-10341, 2020 Cited by PubMed: 32663306DOI: 10.1093/nar/gkaa604 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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