2LDM

Solution structure of human PHF20 Tudor2 domain bound to a p53 segment containing a dimethyllysine analog p53K370me2

Summary for 2LDM

• Entry DOI: 10.2210/pdb2ldm/pdb
• NMR Information: BMRB: 17673
• Descriptor: Uncharacterized protein (1 entity in total)
• Functional Keywords: phf20, tudor domain, epigenetics, methylated p53, transcription factor, transcription-protein binding complex, transcription/protein binding
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 9070.21

Authors

Cui, G.,Botuyan, M.,Mer, G. (deposition date: 2011-05-30, release date: 2012-05-30, Last modification date: 2023-11-15)

• Primary citation: Cui, G.,Park, S.,Badeaux, A.I.,Kim, D.,Lee, J.,Thompson, J.R.,Yan, F.,Kaneko, S.,Yuan, Z.,Botuyan, M.V.,Bedford, M.T.,Cheng, J.Q.,Mer, G.; PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.; Nat.Struct.Mol.Biol., 19:916-924, 2012; PubMed: 22864287; DOI: 10.1038/nsmb.2353

Experimental method

SOLUTION NMR