8F8Y

PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide

Summary for 8F8Y

Entry DOI	10.2210/pdb8f8y/pdb
Descriptor	Lysine-specific demethylase PHF2, Serine/threonine-protein kinase VRK1 N-terminus peptide, ZINC ION, ... (6 entities in total)
Functional Keywords	methyl-lysine binding, aromatic cage, plant homeodomain, phd, jumonji domain, plant homeodomain finger 2, phf2, histone h3 lysine 4 tri-methylation, h3k4me3, protein binding, oxidoreductase-transferase complex, oxidoreductase/transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	108598.67
Authors	Horton, J.R.,Cheng, X. (deposition date: 2022-11-22, release date: 2023-01-18, Last modification date: 2023-02-08)
Primary citation	Horton, J.R.,Zhou, J.,Chen, Q.,Zhang, X.,Bedford, M.T.,Cheng, X. A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299:102862-102862, 2022 Cited by PubMed: 36596360 DOI: 10.1016/j.jbc.2022.102862 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.06 Å)

Structure validation