7NUD
Crystal structure of mouse PRMT6 in complex with inhibitor EML734
Summary for 7NUD
| Entry DOI | 10.2210/pdb7nud/pdb |
| Descriptor | Protein arginine N-methyltransferase 6, methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate (3 entities in total) |
| Functional Keywords | sam binding domain, arginine methylation, transferase |
| Biological source | Mus musculus (house mouse) |
| Total number of polymer chains | 2 |
| Total formula weight | 86859.81 |
| Authors | Bonnefond, L.,Cavarelli, J. (deposition date: 2021-03-11, release date: 2022-03-23, Last modification date: 2024-01-31) |
| Primary citation | Iannelli, G.,Milite, C.,Marechal, N.,Cura, V.,Bonnefond, L.,Troffer-Charlier, N.,Feoli, A.,Rescigno, D.,Wang, Y.,Cipriano, A.,Viviano, M.,Bedford, M.T.,Cavarelli, J.,Castellano, S.,Sbardella, G. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65:11574-11606, 2022 Cited by PubMed: 35482954DOI: 10.1021/acs.jmedchem.2c00252 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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