7NUD
Crystal structure of mouse PRMT6 in complex with inhibitor EML734
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protein arginine N-methyltransferase 6 | polymer | 386 | 42821.3 | 2 | UniProt (Q6NZB1) Pfam (PF13649) Pfam (PF22528) In PDB | Mus musculus (house mouse) | |
2 | A, B | methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate | non-polymer | 608.6 | 2 | Chemie (LRZ) | |||
3 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 378 (UniProt: Q6NZB1)
PDB | External Database | Details |
---|---|---|
Leu 315 | Phe 315 | engineered mutation |
Gly 379 | - | expression tag |
Ser 380 | - | expression tag |
Glu 381 | - | expression tag |
Asn 382 | - | expression tag |
Leu 383 | - | expression tag |
Tyr 384 | - | expression tag |
Phe 385 | - | expression tag |
Gln 386 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85642.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1217.2 | |
All* | Total formula weight | 86859.8 |