3QO2

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9

Summary for 3QO2

• Entry DOI: 10.2210/pdb3qo2/pdb
• Descriptor: M-phase phosphoprotein 8, Histone H3 peptide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: epigenetics, mpp8 phosphorylation, chromodomain, mpp8-h3k9me modulates the expression of e-cadherin, h3k9 methyl-lysine binding, tri-methyl-lysine, dna binding protein-gene regulation complex, histone h3 tail binding protein, dna binding protein/gene regulation
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q99549
• Total number of polymer chains: 8
• Total formula weight: 37072.49

Authors

Chang, Y.,Horton, J.R.,Bedford, M.T.,Zhang, X.,Cheng, X. (deposition date: 2011-02-09, release date: 2011-04-06, Last modification date: 2023-09-13)

• Primary citation: Chang, Y.,Horton, J.R.,Bedford, M.T.,Zhang, X.,Cheng, X.; Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.; J.Mol.Biol., 408:807-814, 2011; PubMed: 21419134; DOI: 10.1016/j.jmb.2011.03.018

Experimental method

X-RAY DIFFRACTION (2.49 Å)