2ACX
 
 | | Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP | | Descriptor: | G protein-coupled receptor kinase 6, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Lodowski, D.T, Tesmer, V.M, Benovic, J.L, Tesmer, J.J. | | Deposit date: | 2005-07-19 | | Release date: | 2006-04-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs.
J.Biol.Chem., 281, 2006
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1TXD
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1X86
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3PSC
 | | Bovine GRK2 in complex with Gbetagamma subunits | | Descriptor: | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | | Authors: | Thal, D.M, Tesmer, J.J. | | Deposit date: | 2010-12-01 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
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3PVU
 | | Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101) | | Descriptor: | 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Thal, D.M, Tesmer, J.J. | | Deposit date: | 2010-12-07 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
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3PVW
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1AZS
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1GPM
 | | ESCHERICHIA COLI GMP SYNTHETASE COMPLEXED WITH AMP AND PYROPHOSPHATE | | Descriptor: | ADENOSINE MONOPHOSPHATE, CITRIC ACID, GMP SYNTHETASE, ... | | Authors: | Tesmer, J.J.G. | | Deposit date: | 1995-04-04 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nat.Struct.Biol., 3, 1996
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1CJV
 | | COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN | | Descriptor: | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... | | Authors: | Tesmer, J.J.G, Sprang, S.R. | | Deposit date: | 1999-04-19 | | Release date: | 1999-08-31 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
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1CJT
 | | COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG | | Descriptor: | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... | | Authors: | Tesmer, J.J.G, Sprang, S.R. | | Deposit date: | 1999-04-16 | | Release date: | 1999-08-31 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
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1CJK
 | | COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ... | | Authors: | Tesmer, J.J.G, Sprang, S.R. | | Deposit date: | 1999-04-16 | | Release date: | 1999-08-31 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
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1CJU
 | | COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG | | Descriptor: | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENYLATE CYCLASE, ... | | Authors: | Tesmer, J.J.G, Sprang, S.R. | | Deposit date: | 1999-04-16 | | Release date: | 1999-08-31 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
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1AGR
 | | COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4 | | Descriptor: | CITRIC ACID, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Tesmer, J.J.G, Sprang, S.R. | | Deposit date: | 1997-03-25 | | Release date: | 1997-06-16 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Cell(Cambridge,Mass.), 89, 1997
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3CIK
 | | Human GRK2 in Complex with Gbetagamma subunits | | Descriptor: | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Tesmer, J.J.G, Lodowski, D.T. | | Deposit date: | 2008-03-11 | | Release date: | 2009-02-17 | | Last modified: | 2012-03-07 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
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3KRW
 | | Human GRK2 in complex with Gbetgamma subunits and balanol (soak) | | Descriptor: | BALANOL, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Tesmer, J.J.G, Tesmer, V.M. | | Deposit date: | 2009-11-19 | | Release date: | 2010-02-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
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3KRX
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1CS4
 | | COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG | | Descriptor: | 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... | | Authors: | Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R. | | Deposit date: | 1999-08-16 | | Release date: | 2001-01-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
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3T8O
 | | Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | | Authors: | Tesmer, J.J.G, Singh, P, Nance, M.R. | | Deposit date: | 2011-08-01 | | Release date: | 2012-06-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of a monomeric variant of rhodopsin kinase at 2.5 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
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1CUL
 | | COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG | | Descriptor: | 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... | | Authors: | Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R. | | Deposit date: | 1999-08-20 | | Release date: | 2001-01-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
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7ABP
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8ABP
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4WBO
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4X90
 | | Crystal structure of Lysosomal Phospholipase A2 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Glukhova, A, Tesmer, J.J.G. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
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4X94
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4WNK
 | | Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022 | | Descriptor: | (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, G protein-coupled receptor kinase 5, SULFATE ION | | Authors: | Homan, K.T, Tesmer, J.J.G. | | Deposit date: | 2014-10-13 | | Release date: | 2015-06-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.
J.Biol.Chem., 290, 2015
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