4WNK

Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022

Summary for 4WNK

Entry DOI	10.2210/pdb4wnk/pdb
Related	3NYN 4MKO
Descriptor	G protein-coupled receptor kinase 5, (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	g protein-coupled receptor kinase 5, hydrolase, phosphorylation, cardiovascular disease, ligase
Biological source	Bos taurus (Bovine)
Total number of polymer chains	1
Total formula weight	69633.42
Authors	Homan, K.T.,Tesmer, J.J.G. (deposition date: 2014-10-13, release date: 2015-06-10, Last modification date: 2023-09-27)
Primary citation	Homan, K.T.,Waldschmidt, H.V.,Glukhova, A.,Cannavo, A.,Song, J.,Cheung, J.Y.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J. Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J.Biol.Chem., 290:20649-20659, 2015 Cited by PubMed: 26032411 DOI: 10.1074/jbc.M115.647370 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation