Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue 453 A 701 |
| Chain | Residue |
| A | LEU192 |
| A | LYS215 |
| A | LEU217 |
| A | MET230 |
| A | GLU234 |
| A | THR264 |
| A | ILE265 |
| A | MET266 |
| A | GLU315 |
| A | ASN316 |
| A | LEU318 |
| A | GLY193 |
| A | SER328 |
| A | ASP329 |
| A | HOH804 |
| A | HOH817 |
| A | LYS194 |
| A | GLY195 |
| A | GLY196 |
| A | PHE197 |
| A | GLY198 |
| A | VAL200 |
| A | ALA213 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 702 |
| Chain | Residue |
| A | LYS183 |
| A | THR255 |
| A | LYS256 |
| A | HOH837 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 33 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGEVCaCqvratgkmyackrlekk.RIKK |
| Chain | Residue | Details |
| A | LEU192-LYS224 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvYrDLKpeNILL |
| Chain | Residue | Details |
| A | ILE307-LEU319 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 118 |
| Details | Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 262 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
