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2I68
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CRYO-EM BASED THEORETICAL MODEL STRUCTURE OF TRANSMEMBRANE DOMAIN OF THE MULTIDRUG-RESISTANCE ANTIPORTER FROM E. COLI EMRE
Descriptor:Protein emrE
Authors:Fleishman, S.J., Harrington, S.E., Enosh, A., Halperin, D., Tate, C.G., Ben-Tal, N.
Deposit date:2006-08-28
Release date:2006-10-03
Last modified:2011-07-13
Method:ELECTRON CRYSTALLOGRAPHY (7.5 Å)
Cite:Quasi-symmetry in the Cryo-EM Structure of EmrE Provides the Key to Modeling its Transmembrane Domain
J.Mol.Biol., 364, 2006
2VT4
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL
Descriptor:BETA1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, SODIUM ION, ...
Authors:Warne, A., Serrano-Vega, M.J., Baker, J.G., Moukhametzianov, R., Edwards, P.C., Henderson, R., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2008-05-09
Release date:2008-06-24
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a Beta1-Adrenergic G-Protein-Coupled Receptor.
Nature, 454, 2008
2Y00
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y01
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-03-30
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y02
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST CARMOTEROL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y03
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y04
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2YCW
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, HEGA-10, ...
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCX
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCY
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL, ...
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCZ
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YDO
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH ADENOSINE BOUND
Descriptor:ADENOSINE RECEPTOR A2A, ADENOSINE, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G.
Deposit date:2011-03-23
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
2YDV
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH NECA BOUND
Descriptor:ADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G.
Deposit date:2011-03-24
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
3PWH
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THERMOSTABILISED ADENOSINE A2A RECEPTOR
Descriptor:Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Authors:Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Tehan, B., Hurrell, E., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Deposit date:2010-12-08
Release date:2011-09-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (3.296 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3REY
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THERMOSTABILISED ADENOSINE A2A RECEPTOR IN COMPLEX WITH XAC
Descriptor:Adenosine receptor A2a, N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetamide
Authors:Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Hollenstein, K., Tehan, B., Hurrell, E., Bennett, K., Congreve, M., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Deposit date:2011-04-05
Release date:2011-09-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (3.309 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3RFM
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THERMOSTABILISED ADENOSINE A2A RECEPTOR IN COMPLEX WITH CAFFEINE
Descriptor:Adenosine receptor A2a, CAFFEINE
Authors:Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Hollenstein, K., Tehan, B., Hurrell, E., Bennett, K., Congreve, M., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Deposit date:2011-04-06
Release date:2011-09-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3ZPQ
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THERMOSTABILISED TURKEY BETA1 ADRENERGIC RECEPTOR WITH 4-(PIPERAZIN-1- YL)-1H-INDOLE BOUND (COMPOUND 19)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Christopher, J.A., Congreve, M., Dore, A.S., Marshall, F.H., Myszka, D.G., Brown, J., Koglin, M., Tehan, B., Errey, J.C., Tate, C.G., Warne, T.
Deposit date:2013-03-01
Release date:2013-04-03
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
J.Med.Chem., 56, 2013
3ZPR
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THERMOSTABILISED TURKEY BETA1 ADRENERGIC RECEPTOR WITH 4-METHYL-2-(PIPERAZIN-1-YL) QUINOLINE BOUND
Descriptor:BETA-1 ADRENERGIC RECEPTOR, SODIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Christopher, J.A., Congreve, M., Dore, A.S., Marshall, F.H., Myszka, D.G., Brown, J., Koglin, M., Tehan, B., Errey, J.C., Tate, C.G., Warne, T.
Deposit date:2013-03-01
Release date:2013-04-03
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
J.Med.Chem., 56, 2013
4AMI
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND BIASED AGONIST BUCINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 2-[(2S)-3-[[1-(1H-indol-3-yl)-2-methyl-propan-2-yl]amino]-2-oxidanyl-propoxy]benzenecarbonitrile, HEGA-10
Authors:Warne, T., Edwards, P.C., Leslie, A.G., Tate, C.G.
Deposit date:2012-03-11
Release date:2012-05-23
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
4AMJ
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND BIASED AGONIST CARVEDILOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, (2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL, SODIUM ION, ...
Authors:Warne, T., Edwards, P.C., Leslie, A.G., Tate, C.G.
Deposit date:2012-03-12
Release date:2012-05-23
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
4BVN
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ULTRA-THERMOSTABLE BETA1-ADRENOCEPTOR WITH CYANOPINDOLOL BOUND
Descriptor:BETA-1 ADRENERGIC RECEPTOR, SODIUM ION, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, ...
Authors:Miller, J., Nehme, R., Warne, T., Edwards, P.C., Leslie, A.G.W., Schertler, G., Tate, C.G.
Deposit date:2013-06-26
Release date:2014-04-02
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The 2.1 A Resolution Structure of Cyanopindolol-Bound Beta1- Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor.
Plos One, 9, 2014
4GRV
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THE CRYSTAL STRUCTURE OF THE NEUROTENSIN RECEPTOR NTS1 IN COMPLEX WITH NEUROTENSIN (8-13)
Descriptor:Neurotensin receptor type 1, lysozyme chimera, Neurotensin 8-13, ...
Authors:Noinaj, N., White, J.F., Shibata, Y., Love, J., Kloss, B., Xu, F., Gvozdenovic-Jeremic, J., Shah, P., Shiloach, J., Tate, C.G., Grisshammer, R.
Deposit date:2012-08-27
Release date:2012-10-17
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure of the agonist-bound neurotensin receptor.
Nature, 490, 2012
4UG2
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH CGS21680 BOUND
Descriptor:THERMOSTABILISED HUMAN A2A RECEPTOR, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE
Authors:Lebon, G., Edwards, P.C., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-03-21
Release date:2015-04-08
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
4UHR
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH CGS21680 BOUND
Descriptor:THERMOSTABILISED HUMAN A2A RECEPTOR, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE
Authors:Lebon, G., Edwards, P.C., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-03-25
Release date:2015-04-08
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
5A8E
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THERMOSTABILISED BETA1-ADRENOCEPTOR WITH RATIONALLY DESIGNED INVERSE AGONIST 7-METHYLCYANOPINDOLOL BOUND
Descriptor:BETA1 ADRENERGIC RECEPTOR, SODIUM ION, 4-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-7-methyl-1H-indole-2-carbonitrile, ...
Authors:Sato, T., Baker, J.G., Warne, T., Brown, G.A., Congreve, M., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-07-15
Release date:2015-09-30
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound Beta1-Adrenergic Receptor.
Mol.Pharmacol., 88, 2015
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