Author results

2P5E
  • Download 2p5e
  • View 2p5e
Molmil generated image of 2p5e
CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEAL NATIVE DIAGONAL BINDING GEOMETRY
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-03-15
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2P5W
  • Download 2p5w
  • View 2p5w
Molmil generated image of 2p5w
CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEAL NATIVE DIAGONAL BINDING GEOMETRY
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-03-16
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2PYE
  • Download 2pye
  • View 2pye
Molmil generated image of 2pye
CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEALNATIVE DIAGONAL BINDING GEOMETRY TCR CLONE C5C1 COMPLEXED WITH MHC
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-05-16
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2PYF
  • Download 2pyf
  • View 2pyf
Molmil generated image of 2pyf
CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEALNATIVE DIAGONAL BINDING GEOMETRY UNBOUND TCR CLONE 5-1
Descriptor:T-Cell Receptor, Alpha Chain, Beta Chain, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-05-16
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
5BRZ
  • Download 5brz
  • View 5brz
Molmil generated image of 5brz
MAGE-A3 REACTIVE TCR IN COMPLEX WITH MAGE-A3 IN HLA-A1
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Raman, M.C.C., Rizkallah, P.J., Simmons, R., Donnellan, Z., Dukes, J., Bossi, G., LeProvost, G., Mahon, T., Hickman, E., LomaX, M., Oates, J., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
5BS0
  • Download 5bs0
  • View 5bs0
Molmil generated image of 5bs0
MAGE-A3 REACTIVE TCR IN COMPLEX WITH TITIN EPITOPE IN HLA-A1
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Raman, M.C.C., Rizkallah, P.J., Simmons, R., Donellan, Z., Dukes, J., Bossi, G., LeProvost, G., Mahon, T., Hickman, E., Lomax, M., Oates, J., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
2BJS
  • Download 2bjs
  • View 2bjs
Molmil generated image of 2bjs
ISOPENICILLIN N SYNTHASE C-TERMINAL TRUNCATION MUTANT
Descriptor:ISOPENICILLIN N SYNTHETASE, FE (III) ION, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ...
Authors:McNeill, L.A., Sami, M., Clifton, I.J., Burzlaff, N.I.
Deposit date:2005-02-07
Release date:2006-03-09
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.
Chemistry, 23, 2017
2BNQ
  • Download 2bnq
  • View 2bnq
Molmil generated image of 2bnq
STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNR
  • Download 2bnr
  • View 2bnr
Molmil generated image of 2bnr
STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNU
  • Download 2bnu
  • View 2bnu
Molmil generated image of 2bnu
STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., Van Der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-04-04
Release date:2005-05-24
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
2F53
  • Download 2f53
  • View 2f53
Molmil generated image of 2f53
DIRECTED EVOLUTION OF HUMAN T-CELL RECEPTOR CDR2 RESIDUES BY PHAGE DISPLAY DRAMATICALLY ENHANCES AFFINITY FOR COGNATE PEPTIDE-MHC WITHOUT APPARENT CROSS-REACTIVITY
Descriptor:HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Dunn, S.M., Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2F54
  • Download 2f54
  • View 2f54
Molmil generated image of 2f54
DIRECTED EVOLUTION OF HUMAN T CELL RECEPTOR CDR2 RESIDUES BY PHAGE DISPLAY DRAMATICALLY ENHANCES AFFINITY FOR COGNATE PEPTIDE-MHC WITHOUT INCREASING APPARENT CROSS-REACTIVITY
Descriptor:HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Dunn, S.M., Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2HP4
  • Download 2hp4
  • View 2hp4
Molmil generated image of 2hp4
COMPUTATIONAL DESIGN AND CRYSTAL STRUCTURE OF AN ENHANCED AFFINITY MUTANT HUMAN CD8-ALPHA-ALPHA CO-RECEPTOR
Descriptor:T-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL
Authors:Rizkallah, P.J., Cole, D.K., Jakobsen, B.K., Boulter, J.M., Glick, M., Gao, G.F.
Deposit date:2006-07-17
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
Proteins, 67, 2007
4JFD
  • Download 4jfd
  • View 4jfd
Molmil generated image of 4jfd
PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFE
  • Download 4jfe
  • View 4jfe
Molmil generated image of 4jfe
PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFF
  • Download 4jff
  • View 4jff
Molmil generated image of 4jff
PRESERVATION OF PEPTIDE SPECIFICITY DURING TCR-MHC CONTACT DOMINATED AFFINITY ENHANCEMENT OF A MELANOMA-SPECIFIC TCR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFH
  • Download 4jfh
  • View 4jfh
Molmil generated image of 4jfh
HIGH AFFINITY ALPHA24-BETA17 T CELL RECEPTOR FOR A2 HLA-MELANOMA PEPTIDE COMPLEX
Descriptor:alpha24 TCR allele, beta17 TCR allele, 1,2-ETHANEDIOL, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFO
  • Download 4jfo
  • View 4jfo
Molmil generated image of 4jfo
A2 HLA COMPLEX WITH E1A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K., Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFP
  • Download 4jfp
  • View 4jfp
Molmil generated image of 4jfp
A2 HLA COMPLEX WITH G4A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFQ
  • Download 4jfq
  • View 4jfq
Molmil generated image of 4jfq
A2 HLA COMPLEX WITH L8A HETEROCLITIC VARIANT OF MELANOMA PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Madura, F., Sewell, A.K., Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
2BCK
  • Download 2bck
  • View 2bck
Molmil generated image of 2bck
CRYSTAL STRUCTURE OF HLA-A*2402 COMPLEXED WITH A TELOMERASE PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Cole, D.K., Gao, G.F.
Deposit date:2005-10-19
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
Eur.J.Immunol., 36, 2006
4GRM
  • Download 4grm
  • View 4grm
Molmil generated image of 4grm
THE CRYSTAL STRUCTURE OF THE HIGH AFFINITY TCR A6
Descriptor:A6 alpha chain, A6 beta chain
Authors:Borbulevych, O.Y., Scott, D.R., Baker, B.M.
Deposit date:2012-08-25
Release date:2013-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.
Front Immunol, 4, 2013
4MNQ
  • Download 4mnq
  • View 4mnq
Molmil generated image of 4mnq
TCR-PEPTIDE SPECIFICITY OVERRIDES AFFINITY ENHANCING TCR-MHC INTERACTIONS
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Jakobsen, B.K.
Deposit date:2013-09-11
Release date:2013-11-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.742 Å)
Cite:T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014