5BRZ
MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1
Summary for 5BRZ
Entry DOI | 10.2210/pdb5brz/pdb |
Related | 5BS0 |
Descriptor | HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, GLU-VAL-ASP-PRO-ILE-GLY-HIS-LEU-TYR, ... (7 entities in total) |
Functional Keywords | immuno pmhc tcr mage, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P30443 Secreted : P61769 Membrane ; Single-pass membrane protein : P01848 |
Total number of polymer chains | 5 |
Total formula weight | 93912.98 |
Authors | Raman, M.C.C.,Rizkallah, P.J.,Simmons, R.,Donnellan, Z.,Dukes, J.,Bossi, G.,LeProvost, G.,Mahon, T.,Hickman, E.,LomaX, M.,Oates, J.,Hassan, N.,Vuidepot, A.,Sami, M.,Cole, D.K.,Jakobsen, B.K. (deposition date: 2015-06-01, release date: 2016-03-02, Last modification date: 2024-01-10) |
Primary citation | Raman, M.C.,Rizkallah, P.J.,Simmons, R.,Donnellan, Z.,Dukes, J.,Bossi, G.,Le Provost, G.S.,Todorov, P.,Baston, E.,Hickman, E.,Mahon, T.,Hassan, N.,Vuidepot, A.,Sami, M.,Cole, D.K.,Jakobsen, B.K. Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Sci Rep, 6:18851-18851, 2016 Cited by PubMed: 26758806DOI: 10.1038/srep18851 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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