4JFF

Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR

Summary for 4JFF
Related4JFD 4JFE 4JFH 4JFO 4JFP 4JFQ
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma motif, ... (8 entities in total)
Functional Keywordshla, tcr, melanoma motif, immune system, high affinity
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted: P61769
Total number of polymer chains5
Total formula weight95374.64
Authors
Rizkallah, P.J.,Cole, D.K.,Madura, F.,Sewell, A.K. (deposition date: 2013-02-28, release date: 2013-05-29, Last modification date: 2014-04-02)
Primary citationBaker, B.M.,Bulek, A.M.,Cole, D.K.,Fuller, A.,Holland, C.J.,Hossain, M.,Jakobsen, B.K.,Li, Y.,Liddy, N.,Madura, F.,Miles, J.J.,Miles, K.M.,Rizkallah, P.J.,Sami, M.,Schauenburg, A.J.,Sewell, A.K.
T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288:18766-18775, 2013
PubMed: 23698002
DOI: 110.1074/jbc.M113.464560
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.43 Å)
Structure validation
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PDB entries from 2021-06-23