4JFF
Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | C (C) | Melanoma motif | polymer | 10 | 985.2 | 1 | UniProt (by SIFTS) (Q16655) | Homo sapiens | |
| 4 | D (D) | High Affinity TCR Alpha Chain | polymer | 197 | 21887.1 | 1 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 5 | E (E) | High Affinity TCR Beta Chain | polymer | 245 | 27522.7 | 1 | Pfam (PF07654) UniProt (by SIFTS) (P01850) | Homo sapiens (human) | |
| 6 | F, K (A, E) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 7 | G, H, I, J, L... (A, D, E) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 8 | O, P, Q, R, S (A, B, C, D, E) | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94225.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1149.1 | |
| All* | Total formula weight | 95374.6 |
