2HP4

Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor

Summary for 2HP4

DescriptorT-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywordscd8, co-receptor, soluble protein, kd, protein engineering, immunotherapy, immune-suppressor, immune system
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted P01732
Total number of polymer chains2
Total molecular weight26537.72
Authors
Rizkallah, P.J.,Cole, D.K.,Jakobsen, B.K.,Boulter, J.M.,Glick, M.,Gao, G.F. (deposition date: 2006-07-17, release date: 2007-02-06, Last modification date: 2011-07-13)
Primary citation
Cole, D.K.,Rizkallah, P.J.,Boulter, J.M.,Sami, M.,Vuidepot, A.-L.,Glick, M.,Gao, F.,Bell, J.I.,Jakobsen, B.K.,Gao, G.F.
Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
Proteins, 67:65-74, 2007
PubMed: 17243170 (PDB entries with the same primary citation)
DOI: 10.1002/prot.21176
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22881.8%1.5%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2hp4
no rotation
Molmil generated image of 2hp4
rotated about x axis by 90°
Molmil generated image of 2hp4
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2hp4
no rotation
Molmil generated image of 2hp4
rotated about x axis by 90°
Molmil generated image of 2hp4
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2hp4.pdb1.gz [45.52 KB])
Coordinate files for Biological unit (2hp4.pdb2.gz [88.21 KB])