2HP4
Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | T-cell surface glycoprotein CD8 alpha chain | polymer | 114 | 12844.5 | 2 | UniProt (P01732) Pfam (PF07686) | Homo sapiens (human) | T-lymphocyte differentiation antigen T8/Leu-2, CD8a antigen |
| 2 | C, D, E, F, I (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | G, H, J, K (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | L, M (A, B) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 114 (UniProt: P01732)
| PDB | External Database | Details |
|---|---|---|
| Ala 33 | Cys 54 | engineered mutation |
| Asn 53 | Ser 74 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25689.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 848.7 | |
| All* | Total formula weight | 26537.7 |
