2BNU

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Summary for 2BNU

DescriptorT-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION (3 entities in total)
Functional Keywordssuperagonist peptide t-cell vaccines, receptor, t-cell, transmembrane, immunoglobulin domain, immune system/receptor, immune system-receptor complex
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMembrane ; Single-pass membrane protein  P01848 P01848
Total number of polymer chains2
Total molecular weight49219.58
Authors
Primary citation
Chen, J.-L.,Stewart-Jones, G.,Bossi, G.,Lissin, N.M.,Wooldridge, L.,Choi, E.M.L.,Held, G.,Dunbar, P.R.,Esnouf, R.M.,Sami, M.,Boulter, J.M.,Rizkallah, P.,Renner, C.,Sewell, A.,Van Der Merwe, P.A.,Jakobsen, B.K.,Griffiths, G.,Jones, E.Y.,Cerundolo, V.
Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201:1243-, 2005
PubMed: 15837811 (PDB entries with the same primary citation)
DOI: 10.1084/JEM.20042323
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers161.4%2.6%19.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution