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4JFE

Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR

Summary for 4JFE
Entry DOI10.2210/pdb4jfe/pdb
Related4JFD 4JFF 4JFH 4JFO 4JFP 4JFQ
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma peptide L7A, ... (8 entities in total)
Functional Keywordshla, tcr, melanoma, immune system, high affinity
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains5
Total formula weight94751.95
Authors
Rizkallah, P.J.,Cole, D.K.,Madura, F.,Sewell, A.K. (deposition date: 2013-02-28, release date: 2013-05-29, Last modification date: 2017-11-15)
Primary citationMadura, F.,Rizkallah, P.J.,Miles, K.M.,Holland, C.J.,Bulek, A.M.,Fuller, A.,Schauenburg, A.J.,Miles, J.J.,Liddy, N.,Sami, M.,Li, Y.,Hossain, M.,Baker, B.M.,Jakobsen, B.K.,Sewell, A.K.,Cole, D.K.
T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288:18766-18775, 2013
Cited by
PubMed: 23698002
DOI: 10.1074/jbc.M113.464560
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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