4JFE
Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | C (C) | Melanoma peptide L7A | polymer | 10 | 943.1 | 1 | |||
| 4 | D (D) | High Affinity TCR Alpha Chain | polymer | 197 | 21887.1 | 1 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 5 | E (E) | High Affinity TCR Beta Chain | polymer | 245 | 27522.7 | 1 | Pfam (PF07654) UniProt (by SIFTS) (P01850) | Homo sapiens (human) | |
| 6 | F, G, I, K (A, D, E) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 7 | H, J (D, E) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | L, M, N, O (A, B, D, E) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94183.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 568.4 | |
| All* | Total formula weight | 94751.9 |
