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1BET
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BU of 1bet by Molmil
NEW PROTEIN FOLD REVEALED BY A 2.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF NERVE GROWTH FACTOR
Descriptor: BETA-NERVE GROWTH FACTOR
Authors:Mcdonald, N.Q, Lapatto, R, Murray-Rust, J, Gunning, J, Wlodawer, A, Blundell, T.L.
Deposit date:1993-04-08
Release date:1994-05-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.
Nature, 354, 1991
1CNT
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BU of 1cnt by Molmil
CILIARY NEUROTROPHIC FACTOR
Descriptor: CILIARY NEUROTROPHIC FACTOR, SULFATE ION, YTTERBIUM (III) ION
Authors:Mcdonald, N.Q, Panayotatos, N, Hendrickson, W.A.
Deposit date:1996-06-06
Release date:1997-03-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.
EMBO J., 14, 1995
6FEK
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BU of 6fek by Molmil
Oncogenic point mutation of RET receptor tyrosine kinase
Descriptor: ADENOSINE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret
Authors:McDonald, N.Q, Kohno, T.
Deposit date:2018-01-02
Release date:2018-02-28
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A secondary RET mutation in the activation loop conferring resistance to vandetanib.
Nat Commun, 9, 2018
8OS6
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BU of 8os6 by Molmil
Structure of a GFRA1/GDNF LICAM complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Houghton, F.M, Adams, S.E, Briggs, D.C, McDonald, N.Q.
Deposit date:2023-04-18
Release date:2023-11-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Architecture and regulation of a GDNF-GFR alpha 1 synaptic adhesion assembly.
Nat Commun, 14, 2023
1SGF
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BU of 1sgf by Molmil
CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NERVE GROWTH FACTOR, ...
Authors:Bax, B.D.V, Blundell, T.L, Murray-Rust, J, Mcdonald, N.Q.
Deposit date:1997-08-08
Release date:1998-05-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Structure, 5, 1997
4UU6
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BU of 4uu6 by Molmil
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF PALS1
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Ivanova, M.E, Purkiss, A.G, McDonald, N.Q.
Deposit date:2014-07-24
Release date:2015-01-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
7NZN
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BU of 7nzn by Molmil
Structure of RET kinase domain bound to inhibitor JB-48
Descriptor: 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{N}-(3-fluorophenyl)ethanamide, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret
Authors:Briggs, D.C, McDonald, N.Q.
Deposit date:2021-03-24
Release date:2022-02-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
J.Med.Chem., 65, 2022
7AB8
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BU of 7ab8 by Molmil
Crystal structure of a GDNF-GFRalpha1 complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-09-07
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7AML
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BU of 7aml by Molmil
RET/GDNF/GFRa1 extracellular complex Cryo-EM structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-10-09
Release date:2021-01-13
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7AMK
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BU of 7amk by Molmil
Zebrafish RET Cadherin Like Domains 1 to 4.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Purkiss, A.G, McDonald, N.Q, Goodman, K.M, Narowtek, A, Knowles, P.P.
Deposit date:2020-10-09
Release date:2021-02-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
4CKI
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BU of 4cki by Molmil
Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine
Descriptor: ADENOSINE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET
Authors:Plaza-Menacho, I, Barnouin, K, Goodman, K, Martinez-Torres, R.J, Borg, A, Murray-Rust, J, Mouilleron, S, Knowles, P, McDonald, N.Q.
Deposit date:2014-01-06
Release date:2014-03-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.116 Å)
Cite:Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Mol. Cell, 53, 2014
4CKJ
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BU of 4ckj by Molmil
Crystal structure of RET tyrosine kinase domain bound to adenosine
Descriptor: ADENOSINE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET
Authors:Plaza-Menacho, I, Barnouin, K, Goodman, K, Martinez-Torres, R.J, Borg, A, Murray-Rust, J, Mouilleron, S, Knowles, P, McDonald, N.Q.
Deposit date:2014-01-06
Release date:2014-03-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Mol. Cell, 53, 2014
1MKP
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BU of 1mkp by Molmil
CRYSTAL STRUCTURE OF PYST1 (MKP3)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PYST1
Authors:Stewart, A.E, Dowd, S, Keyse, S, Mcdonald, N.Q.
Deposit date:1998-07-11
Release date:1999-07-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.
Nat.Struct.Biol., 6, 1999
1YZB
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BU of 1yzb by Molmil
Solution structure of the Josephin domain of Ataxin-3
Descriptor: Machado-Joseph disease protein 1
Authors:Nicastro, G, Masino, L, Menon, R.P, Knowles, P.P, McDonald, N.Q, Pastore, A.
Deposit date:2005-02-28
Release date:2005-07-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition
Proc.Natl.Acad.Sci.Usa, 102, 2005
1UW5
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BU of 1uw5 by Molmil
Structure of PITP-alpha complexed to phosphatidylinositol
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM
Authors:Tilley, S.J, Skippen, A, Murray-Rust, J, Cockcroft, S, McDonald, N.Q.
Deposit date:2004-01-30
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-Function Analysis of Human [Corrected] Phosphatidylinositol Transfer Protein Alpha Bound to Phosphatidylinositol.
Structure, 12, 2004
1BDY
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BU of 1bdy by Molmil
C2 DOMAIN FROM PROTEIN KINASE C DELTA
Descriptor: PROTEIN KINASE C
Authors:Pappa, H, Murray-Rust, J, Dekker, L.V, Parker, P.J, Mcdonald, N.Q.
Deposit date:1998-05-11
Release date:1998-10-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the C2 domain from protein kinase C-delta.
Structure, 6, 1998
2X2K
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BU of 2x2k by Molmil
Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor
Descriptor: (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET
Authors:Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q.
Deposit date:2010-01-13
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
Bioorg. Med. Chem., 18, 2010
2X2M
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BU of 2x2m by Molmil
Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor
Descriptor: (3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET
Authors:Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q.
Deposit date:2010-01-13
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
Bioorg. Med. Chem., 18, 2010
2XQN
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BU of 2xqn by Molmil
Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal domain of actin-like protein Arp7A
Descriptor: ACTIN-LIKE PROTEIN 7A, ENABLED HOMOLOG, TESTIN, ...
Authors:Knowles, P.P, Briggs, D.C, Murray-Rust, J, McDonald, N.Q.
Deposit date:2010-09-03
Release date:2011-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
J. Biol. Chem., 286, 2011
6SXB
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BU of 6sxb by Molmil
XPF-ERCC1 Cryo-EM Structure, DNA-Bound form
Descriptor: DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3'), DNA excision repair protein ERCC-1, ...
Authors:Jones, M.L, Briggs, D.C, McDonald, N.Q.
Deposit date:2019-09-25
Release date:2020-03-11
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.
Nat Commun, 11, 2020
6SXA
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BU of 6sxa by Molmil
XPF-ERCC1 Cryo-EM Structure, Apo-form
Descriptor: DNA excision repair protein ERCC-1, DNA repair endonuclease XPF
Authors:Jones, M.L, Briggs, D.C, McDonald, N.Q.
Deposit date:2019-09-25
Release date:2020-03-11
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.
Nat Commun, 11, 2020
4UX8
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BU of 4ux8 by Molmil
RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF FAMILY RECEPTOR ALPHA-1, ...
Authors:Goodman, K, Kjaer, S, Beuron, F, Knowles, P, Nawrotek, A, Burns, E, Purkiss, A, George, R, Santoro, M, Morris, E.P, McDonald, N.Q.
Deposit date:2014-08-19
Release date:2014-10-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association.
Cell Rep., 8, 2014
4UU5
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BU of 4uu5 by Molmil
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF PALS1 IN COMPLEX WITH THE CRB PEPTIDE
Descriptor: 2,2,4,4,6,6,8-heptamethylnonane, CHLORIDE ION, MAGUK P55 SUBFAMILY MEMBER 5, ...
Authors:Ivanova, M.E, Purkiss, A.G, McDonald, N.Q.
Deposit date:2014-07-24
Release date:2015-01-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
2BGW
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BU of 2bgw by Molmil
XPF from Aeropyrum pernix, complex with DNA
Descriptor: 5'-D(*GP*AP*TP*CP*AP*CP*AP*GP*AP*TP *GP*CP*TP*GP*A)-3', 5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*GP *TP*GP*AP*TP*C)-3', MAGNESIUM ION, ...
Authors:Newman, M, Murray-Rust, J, Lally, J, Rudolf, J, Fadden, A, Knowles, P.P, White, M.F, McDonald, N.Q.
Deposit date:2005-01-06
Release date:2005-02-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.
EMBO J., 24, 2005
2BHN
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BU of 2bhn by Molmil
XPF from Aeropyrum pernix
Descriptor: XPF ENDONUCLEASE
Authors:Newman, M, Murray-Rust, J, Lally, J, Rudolf, J, Fadden, A, Knowles, P.P, White, M.F, McDonald, N.Q.
Deposit date:2005-01-14
Release date:2005-02-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.
EMBO J., 24, 2005

 

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