7NZN
Structure of RET kinase domain bound to inhibitor JB-48
Summary for 7NZN
Entry DOI | 10.2210/pdb7nzn/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase receptor Ret, 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{N}-(3-fluorophenyl)ethanamide, FORMIC ACID, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, cancer, receptor tyrosine kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36560.89 |
Authors | Briggs, D.C.,McDonald, N.Q. (deposition date: 2021-03-24, release date: 2022-02-09, Last modification date: 2024-01-31) |
Primary citation | Zhang, L.,Moccia, M.,Briggs, D.C.,Bharate, J.B.,Lakkaniga, N.R.,Knowles, P.,Yan, W.,Tran, P.,Kharbanda, A.,Wang, X.,Leung, Y.K.,Frett, B.,Santoro, M.,McDonald, N.Q.,Carlomagno, F.,Li, H.Y. Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. J.Med.Chem., 65:1536-1551, 2022 Cited by PubMed: 35081714DOI: 10.1021/acs.jmedchem.1c01280 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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