7NZN
Structure of RET kinase domain bound to inhibitor JB-48
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35868.2 | 1 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | B (A) | 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{N}-(3-fluorophenyl)ethanamide | non-polymer | 554.6 | 1 | Chemie (VJH) | |||
| 3 | C, D, E (A) | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 4 | F (A) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35868.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 692.7 | |
| All* | Total formula weight | 36560.9 |
