4CKI
Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine
Summary for 4CKI
Entry DOI | 10.2210/pdb4cki/pdb |
Related | 4CKJ |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, FORMIC ACID, ADENOSINE, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P07949 |
Total number of polymer chains | 1 |
Total formula weight | 36473.54 |
Authors | Plaza-Menacho, I.,Barnouin, K.,Goodman, K.,Martinez-Torres, R.J.,Borg, A.,Murray-Rust, J.,Mouilleron, S.,Knowles, P.,McDonald, N.Q. (deposition date: 2014-01-06, release date: 2014-03-05, Last modification date: 2023-12-20) |
Primary citation | Plaza-Menacho, I.,Barnouin, K.,Goodman, K.,Martinez-Torres, R.J.,Borg, A.,Murray-Rust, J.,Mouilleron, S.,Knowles, P.,McDonald, N.Q. Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol. Cell, 53:738-751, 2014 Cited by PubMed: 24560924DOI: 10.1016/j.molcel.2014.01.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.116 Å) |
Structure validation
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