4CKI
Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | polymer | 314 | 35838.1 | 1 | UniProt (P07949) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | CADHERIN FAMILY MEMBER 12, PROTO-ONCOGENE C-RET |
2 | A | FORMIC ACID | non-polymer | 46.0 | 8 | Chemie (FMT) | |||
3 | A | ADENOSINE | non-polymer | 267.2 | 1 | Chemie (ADN) | |||
4 | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
PDB | External Database | Details |
---|---|---|
Gly 700 | - | expression tag |
Pro 701 | - | expression tag |
Leu 702 | - | expression tag |
Ser 703 | - | expression tag |
Leu 704 | - | expression tag |
Thr 918 | Met 918 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35838.1 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 635.4 | |
All* | Total formula weight | 36473.5 |