4CKI
Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | polymer | 314 | 35838.1 | 1 | UniProt (P07949) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | CADHERIN FAMILY MEMBER 12, PROTO-ONCOGENE C-RET |
| 2 | B, C, D, E, F... (A) | FORMIC ACID | non-polymer | 46.0 | 8 | Chemie (FMT) | |||
| 3 | J (A) | ADENOSINE | non-polymer | 267.2 | 1 | Chemie (ADN) | |||
| 4 | K (A) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
| Thr 918 | Met 918 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35838.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 635.4 | |
| All* | Total formula weight | 36473.5 |
