4CKJ

Crystal structure of RET tyrosine kinase domain bound to adenosine

Summary for 4CKJ

Entry DOI	10.2210/pdb4ckj/pdb
Related	4CKI
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, ADENOSINE, FORMIC ACID, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P07949
Total number of polymer chains	1
Total formula weight	36791.86
Authors	Plaza-Menacho, I.,Barnouin, K.,Goodman, K.,Martinez-Torres, R.J.,Borg, A.,Murray-Rust, J.,Mouilleron, S.,Knowles, P.,McDonald, N.Q. (deposition date: 2014-01-06, release date: 2014-03-05, Last modification date: 2023-12-20)
Primary citation	Plaza-Menacho, I.,Barnouin, K.,Goodman, K.,Martinez-Torres, R.J.,Borg, A.,Murray-Rust, J.,Mouilleron, S.,Knowles, P.,McDonald, N.Q. Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol. Cell, 53:738-751, 2014 Cited by PubMed: 24560924 DOI: 10.1016/j.molcel.2014.01.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation