7AB8

Crystal structure of a GDNF-GFRalpha1 complex

Summary for 7AB8

Entry DOI	10.2210/pdb7ab8/pdb
Descriptor	GDNF family receptor alpha, Glial cell line-derived neurotrophic factor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	vertebrate development, part of the ret-gfl-gfra complex, neurotrophic factor, signaling protein
Biological source	Danio rerio (Zebrafish) More
Total number of polymer chains	2
Total formula weight	35913.70
Authors	Adams, S.E.,Earl, C.P.,Purkiss, A.G.,McDonald, N.Q. (deposition date: 2020-09-07, release date: 2021-01-13, Last modification date: 2024-01-31)
Primary citation	Adams, S.E.,Purkiss, A.G.,Knowles, P.P.,Nans, A.,Briggs, D.C.,Borg, A.,Earl, C.P.,Goodman, K.M.,Nawrotek, A.,Borg, A.J.,McIntosh, P.B.,Houghton, F.M.,Kjaer, S.,McDonald, N.Q. A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29:694-, 2021 Cited by PubMed: 33484636 DOI: 10.1016/j.str.2020.12.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation