6FEK

Oncogenic point mutation of RET receptor tyrosine kinase

Summary for 6FEK

Entry DOI	10.2210/pdb6fek/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase receptor Ret, FORMIC ACID, ADENOSINE, ... (4 entities in total)
Functional Keywords	tyrosine kinase, oncogene, mutation, oncoprotein
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P07949
Total number of polymer chains	1
Total formula weight	34711.00
Authors	McDonald, N.Q.,Kohno, T. (deposition date: 2018-01-02, release date: 2018-02-28, Last modification date: 2018-05-02)
Primary citation	Nakaoku, T.,Kohno, T.,Araki, M.,Niho, S.,Chauhan, R.,Knowles, P.P.,Tsuchihara, K.,Matsumoto, S.,Shimada, Y.,Mimaki, S.,Ishii, G.,Ichikawa, H.,Nagatoishi, S.,Tsumoto, K.,Okuno, Y.,Yoh, K.,McDonald, N.Q.,Goto, K. A secondary RET mutation in the activation loop conferring resistance to vandetanib. Nat Commun, 9:625-625, 2018 Cited by PubMed: 29434222 DOI: 10.1038/s41467-018-02994-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation