6FEK
Oncogenic point mutation of RET receptor tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 299 | 34305.7 | 1 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | B, C, D (A) | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 3 | E (A) | ADENOSINE | non-polymer | 267.2 | 1 | Chemie (ADN) | |||
| 4 | F (A) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
| Ala 713 | Glu 713 | conflict |
| Ala 714 | Asp 714 | conflict |
| - | Tyr 826 | deletion |
| - | Leu 827 | deletion |
| - | Gly 828 | deletion |
| - | Ser 829 | deletion |
| - | Gly 830 | deletion |
| - | Gly 831 | deletion |
| - | Ser 832 | deletion |
| - | Arg 833 | deletion |
| - | Asn 834 | deletion |
| - | Ser 835 | deletion |
| - | Ser 836 | deletion |
| - | Ser 837 | deletion |
| - | Leu 838 | deletion |
| - | Asp 839 | deletion |
| - | His 840 | deletion |
| Phe 904 | Ser 904 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34305.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 405.3 | |
| All* | Total formula weight | 34711.0 |
