6FEK

Oncogenic point mutation of RET receptor tyrosine kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proto-oncogene tyrosine-protein kinase receptor Ret	polymer	299	34305.7	1	UniProt (P07949) Pfam (PF07714) In PDB	Homo sapiens (Human)	Cadherin family member 12,Proto-oncogene c-Ret
2	A	FORMIC ACID	non-polymer		46.0	3	Chemie (FMT)
3	A	ADENOSINE	non-polymer		267.2	1	Chemie (ADN)
4		water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 705 - 1013 (UniProt: P07949)

PDB	External Database	Details
Gly 700	-	expression tag
Pro 701	-	expression tag
Leu 702	-	expression tag
Ser 703	-	expression tag
Leu 704	-	expression tag
Ala 713	Glu 713	conflict
Ala 714	Asp 714	conflict
-	Tyr 826	deletion
-	Leu 827	deletion
-	Gly 828	deletion
-	Ser 829	deletion
-	Gly 830	deletion
-	Gly 831	deletion
-	Ser 832	deletion
-	Arg 833	deletion
-	Asn 834	deletion
-	Ser 835	deletion
-	Ser 836	deletion
-	Ser 837	deletion
-	Leu 838	deletion
-	Asp 839	deletion
-	His 840	deletion
Phe 904	Ser 904	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34305.7
Non-Polymers*	Number of molecules	4
	Total formula weight	405.3
All*	Total formula weight	34711.0

*Water molecules are not included.