1BDY

C2 DOMAIN FROM PROTEIN KINASE C DELTA

Summary for 1BDY

Entry DOI	10.2210/pdb1bdy/pdb
Descriptor	PROTEIN KINASE C (2 entities in total)
Functional Keywords	protein kinase c, c2 domain, calcium, calcium-binding, duplication, atp-binding, transferase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Cytoplasm: P09215
Total number of polymer chains	2
Total formula weight	28028.42
Authors	Pappa, H.,Murray-Rust, J.,Dekker, L.V.,Parker, P.J.,Mcdonald, N.Q. (deposition date: 1998-05-11, release date: 1998-10-14, Last modification date: 2024-02-07)
Primary citation	Pappa, H.,Murray-Rust, J.,Dekker, L.V.,Parker, P.J.,McDonald, N.Q. Crystal structure of the C2 domain from protein kinase C-delta. Structure, 6:885-894, 1998 Cited by PubMed Abstract: The protein kinase C (PKC) family of lipid-dependent serine/theonine kinases plays a central role in many intracellular eukaryotic signalling events. Members of the novel (delta, epsilon, eta, theta) subclass of PKC isotypes lack the Ca2+ dependence of the conventional PKC isotypes and have an N-terminal C2 domain, originally defined as V0 (variable domain zero). Biochemical data suggest that this domain serves to translocate novel PKC family members to the plasma membrane and may influence binding of PKC activators. PubMed: 9687370 DOI: 10.1016/S0969-2126(98)00090-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation