2X2K
Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor
Summary for 2X2K
Entry DOI | 10.2210/pdb2x2k/pdb |
Related | 2IVS 2IVT 2IVU 2IVV 2X2L 2X2M |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, FORMIC ACID, (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one, ... (4 entities in total) |
Functional Keywords | tyrosine kinase, hirschsprung disease, tyrosine-protein kinase, proto-oncogene, phosphoprotein, transferase, phosphotransferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36179.59 |
Authors | Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,McDonald, N.Q. (deposition date: 2010-01-13, release date: 2010-02-09, Last modification date: 2023-12-20) |
Primary citation | Mologni, L.,Rostagno, R.,Brussolo, S.,Knowles, P.P.,Kjaer, S.,Murray-Rust, J.,Rosso, E.,Zambon, A.,Scapozza, L.,McDonald, N.Q.,Lucchini, V.,Gambacorti-Passerini, C. Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18:1482-1496, 2010 Cited by PubMed: 20117004DOI: 10.1016/j.bmc.2010.01.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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